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- Title
雷替曲塞在晚期消化系统肿瘤化疗中的应用.
- Authors
王云峰; 赵洪伟; 孙建民; 张松岩; 王凯; 张玉宝
- Abstract
The most common malignant tumor is digestive system carcinoma. At present, surgery is the primary approach to obtain radical cure. However, a majority of patients has been belonging to the late stage, and missed the best time for surgery because of the characteristics of its occult onset. Therefore, systemic chemotherapy has become an important mean to treat these patients. Now, 5-Fluorouracil based systemic chemotherapy is the main program. But lower efficiencies and higher toxicities, especially higher cardiotoxicity, which limit its clinical application. Raltitrexed, as a novel cytotoxic drug, specifically inhibits the thymidylate synthase to restrain tumor cells replication, and then achieves the anti-tumor effects. The relevant reports show its satisfied clilnical efficiencies in the treatment of pleural mesothelioma, head and neck cancer and colorectal cancer. But the comtrehensive reports about the chemotherapy of raltitrexed for advanced digestive cancer were very few. This paper will analyse the domestic and foreign researches, systematically review its drug regimes and efficiencies for advanced digestive cancer.
- Publication
Progress in Modern Biomedicine, 2016, Vol 16, Issue 2, p369
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2016.02.045