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- Title
Assigning Gene Function in Biosynthetic Pathways: Camalexin and Beyond.
- Authors
Møldrup, Morten Emil; Geu-Flores, Fernando; Halkier, Barbara Ann
- Abstract
This article explores the biosynthetic pathway of camalexin, a plant defense compound in Arabidopsis thaliana. Two studies have conflicting conclusions about the enzymes responsible for certain reactions in the pathway, with one suggesting γ-glutamyl transpeptidase (GGT) and the other suggesting γ-glutamyl peptidase (GGP). The authors of this article provide experimental evidence supporting the role of GGPs in the pathway and discuss the criteria for identifying specific genes in biosynthetic pathways. They found that GGP1 is the main enzyme involved in the pathway, while GGT1 and GGT2 do not play a significant role. The article also highlights the importance of considering multiple criteria when determining the role of genes in metabolic pathways.
- Subjects
GLUTATHIONE transferase; GAMMA-glutamyltransferase; TRANSCRIPTION factors; GREEN fluorescent protein
- Publication
Plant Cell, 2013, Vol 25, Issue 2, p360
- ISSN
1040-4651
- Publication type
Article
- DOI
10.1105/tpc.112.104745