We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
case report on recurrent area postrema syndrome in AQP4-IgG-positive NMOSD.
- Authors
Shrestha, Ramesh; Kharel, Ghanshyam
- Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory condition of the central nervous system caused by severe immune-mediated demyelination and axonal destruction, mainly affecting optic nerves and the spinal cord. We describe a 26-year-old Nepalese woman with recent onset of headache, nausea, vomiting and hiccups indicative of Area Postrema Syndrome (APS). The antibody test for aquaporin-4 was strongly positive. Brain magnetic resonance imaging (MRI) showed a bilateral hyperintense signal in the area postrema (AP). The patient started on methylprednisolone, and then azathioprine was added. However, the patient was readmitted because of tingling in her right upper extremity and sudden onset of tremors. An MRI scan showed an enlarged lesion in AP. Rituximab was started on top of the previous treatment, and a second dose was given after 2 weeks. The patient had been monitored regularly and symptom-free for 5 months. Hence, we emphasize the immediate need for a diagnostic approach for NMOSD management.
- Subjects
NEUROMYELITIS optica; CENTRAL nervous system; SPINAL nerves; MAGNETIC resonance imaging; SPINAL cord; ANTIBODY titer
- Publication
Oxford Medical Case Reports, 2022, Vol 2022, Issue 10, p1
- ISSN
2053-8855
- Publication type
Article
- DOI
10.1093/omcr/omac109