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- Title
Prevalence and Possible Risk Factors of Low Bone Mineral Density in Untreated Female Patients with Systemic Lupus Erythematosus.
- Authors
Sun, Yi-Ning; Feng, Xiu-Yuan; He, Lan; Zeng, Ling-Xia; Hao, Zhi-Ming; Lv, Xiao-Hong; Pu, Dan
- Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation. Different studies have shown decreased bone mineral density (BMD) in patients with SLE. The objective of this study was to investigate the prevalence and possible risk factors of low BMD in untreated female patients with SLE in Chinese population. A total of 119 untreated female patients with SLE were included. BMD was measured at lumbar spine and at total hip by dual-energy X-ray absorptiometry. The associations between decreased BMD and demographic variables, clinical variables, and bone metabolism variables were analyzed. These SLE patients had the following characteristics: mean age was 32.6±11.9 years, mean disease duration was 22.1±34.5 months, and mean SLEDAI was 11.4±5.4. Osteopenia was present in 31.1% of the patients and osteoporosis in 8.5%. A significant negative association between low density lipoprotein cholesterol (LDL-c) and BMD at the lumbar spine (correlation coefficient = −0.242; P=0.023) and total hip (correlation coefficient = −0.259; P=0.019) was shown. These results seem to indicate that increased LDL-c may be an important risk factor for low BMD at lumbar spine and total hip in untreated female SLE patients.
- Subjects
CHINA; BONE metabolism; DISEASE risk factors; STATISTICAL correlation; DEMOGRAPHY; LONGITUDINAL method; LOW density lipoproteins; LUMBAR vertebrae; OSTEOPENIA; OSTEOPOROSIS; PROBABILITY theory; RESEARCH funding; STATISTICS; SYSTEMIC lupus erythematosus; T-test (Statistics); DATA analysis; BONE density; BODY mass index; DISEASE prevalence; DISEASE duration; DATA analysis software; DESCRIPTIVE statistics; PHOTON absorptiometry; MANN Whitney U Test; DISEASE complications
- Publication
BioMed Research International, 2015, Vol 2015, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2015/510514