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- Title
Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives.
- Authors
da Silva, Ivanildo Mangueira; Filho, João da Silva; da Silva Santiago, Priscila Brandão Gomes; do Egito, Micalyne Soares; de Souza, Carlos André; Gouveia, Frederico Leite; Ximenes, Rafael Matos; da Fonseca Ribeiro de Sena, Kêsia Xisto; de Faria, Antonio Rodolfo; Brondani, Dalci José; de Albuquerque, Julianna Ferreira Cavalcanti
- Abstract
Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gramnegative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 μg/mL
- Publication
BioMed Research International, 2014, Vol 2014, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2014/316082