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- Title
Caspase-12 Activation is Involved in Amyloid-β Protein-Induced Synaptic Toxicity.
- Authors
Quiroz-Baez, Ricardo; Ferrera, Patricia; Rosendo-Gutiérrez, Rigoberto; Morán, Julio; Bermúdez-Rattoni, Federico; Arias, Clorinda
- Abstract
Synapse loss is considered to be the best correlate of cognitive impairments in Alzheimer's disease (AD), and growing evidence supports the notion that certain events that trigger neuronal death in AD can be initiated by the local activation of caspases within the synaptic compartment. We have demonstrated previously that presynaptic terminals are particularly vulnerable to endoplasmic-reticulum (ER)-stress depending of amyloid-β protein (Aβ). This toxicity included a notable reduction of actin and synaptophysin protein and mitochondrial dysfunction. This synaptic damage was prevented by incubation with a wide range of caspase inhibitor, suggesting the activation of local synaptic apoptotic mechanisms. The ER-resident caspase-12 was initially identified as a mediator of Aβ neurotoxicity. Thus, the current study was conducted to explore the presence and local activation of the caspase-12 in cortical and hippocampal synaptosomes isolated from rat and from the triple transgenic mouse model of AD (3xTg-AD) in the presence of Aβ and ryanodine. Under these conditions, we found mitochondrial failure accompanied by a reduction in actin levels which was dependent on caspase-12 activation suggesting its participation in Aβ-induced synaptic toxicity.
- Subjects
ALZHEIMER'S disease; AMYLOID beta-protein; ENDOPLASMIC reticulum; RYANODINE; ACTIN; APOPTOSIS
- Publication
Journal of Alzheimer's Disease, 2011, Vol 26, Issue 3, p467
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2011-110326