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- Title
A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia.
- Authors
Feng Liu; Fei Sun; Jun Hong Xia; Jian Li; Gui Hong Fu; Grace Lin; Rong Jian Tu; Zi Yi Wan; Delia Quek; Gen Hua Yue
- Abstract
Growth is an important trait in animal breeding. However, the genetic effects underpinning fish growth variability are still poorly understood. QTL mapping and analysis of candidate genes are effective methods to address this issue. We conducted a genome-wide QTL analysis for growth in tilapia. A total of 10, 7 and 8 significant QTLs were identified for body weight, total length and standard length at 140 dph, respectively. The majority of these QTLs were sex-specific. One major QTL for growth traits was identified in the sex-determining locus in LG1, explaining 71.7%, 67.2% and 64.9% of the phenotypic variation (PV) of body weight, total length and standard length, respectively. In addition, a candidate gene GHR2 in a QTL was significantly associated with body weight, explaining 13.1% of PV. Real-time qPCR revealed that different genotypes at the GHR2 locus influenced the IGF-1 expression level. The markers located in the major QTL for growth traits could be used in marker-assisted selection of tilapia. The associations between GHR2 variants and growth traits suggest that the GHR2 gene should be an important gene that explains the difference in growth among tilapia species.
- Subjects
ANIMAL breeding research; TILAPIA; FISH growth; BODY weight; AQUACULTURE; QUANTITATIVE genetics
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep07256