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- Title
8p22-23-rs2254546 as a Susceptibility Locus for Kawasaki Disease: a Case-control Study and a Meta-analysis.
- Authors
Wei Wang; Jiao Lou; Xu-zai Lu; Yan-qi Qi; Na Shen; Rong Zhong; Yu-jia Wang; Li Zou; Qing Zhang; Jia-yu Duan; Jun-tao Ke; Xiao-ping Miao; Fang-qi Gong
- Abstract
8p22-23-rs2254546 was firstly discovered to be associated with Kawasaki disease (KD) susceptibility by a genome-wide association study. However, only one Chinese replication study has been performed so far. To verify this association in another Chinese population, a hospital-based case-control study in Zhejiang province was conducted followed by an integrated meta-analysis, comprising five case-control studies of 1958 cases, 5615 controls and four transmission disequilibrium tests of 503 trios. In our case-control study, significant associations were observed between GG genotype or GG/GA genotypes of rs2254546 and increased KD risk (OR51.86, 95% CI51.01-3.41,P 50.045; OR51.83, 95% CI51.01-3.33,P 50.048), compared with AA genotype; however, no significant association was found in allelic model (OR 5 1.20, 95% CI 5 0.96-1.50, P 5 0.117). The meta-analysis further revealed that the G allele was significantly associated with the increased KD risk without evidence of heterogeneity (OR51.55, 95% CI51.42-1.70,P < 0.001). In conclusion, rs2254546 polymorphism might significantly contribute to the risk of KD.
- Subjects
MUCOCUTANEOUS lymph node syndrome; DISEASE susceptibility; SINGLE nucleotide polymorphisms; CONJUNCTIVITIS; HARDY-Weinberg formula; META-analysis; DISEASE risk factors
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep04247