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- Title
Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer.
- Authors
Liang, Siyuan; Hess, Jochen
- Abstract
The neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune cells and vascular components, forming a polygonal relationship to synergistically facilitate tumor growth and progression. This review comprehensively summarizes the current state of the knowledge on nerve–tumor crosstalk in head and neck cancer and discusses the potential underlying mechanisms. Several mechanisms facilitating nerve–tumor crosstalk are covered, such as perineural invasion, axonogenesis, neurogenesis, neural reprogramming, and transdifferentiation, and the reciprocal interactions between the nervous and immune systems in the TME are also discussed in this review. Further understanding of the nerve–tumor crosstalk in the TME of head and neck cancer may provide new nerve-targeted treatment options and help improve clinical outcomes for patients.
- Subjects
HEAD &; neck cancer; TUMOR growth; NEUROBIOLOGY; TUMORS; NERVOUS system; MEDICAL personnel
- Publication
Cells (2073-4409), 2024, Vol 13, Issue 3, p256
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells13030256