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- Title
Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression.
- Authors
Lin, Tien-Huang; Chang, Sunny Li-Yun; Khanh, Pham Minh; Trang, Nguyen Thi Nha; Liu, Shan-Chi; Tsai, Hsiao-Chi; Chang, An-Chen; Lin, Jo-Yu; Chen, Po-Chun; Liu, Ju-Fang; Guo, Jeng-Hung; Liu, Chun-Lin; Wu, Hsi-Chin; Tang, Chih-Hsin
- Abstract
Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.
- Subjects
APELIN; METASTASIS; PROSTATE cancer; PROSTATE cancer patients; ADIPOKINES; CELL motility
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 20, p3285
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11203285