We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dual Role of p73 in Cancer Microenvironment and DNA Damage Response.
- Authors
Rozenberg, Julian M.; Zvereva, Svetlana; Dalina, Alexandra; Blatov, Igor; Zubarev, Ilya; Luppov, Daniil; Bessmertnyi, Alexander; Romanishin, Alexander; Alsoulaiman, Lamak; Kumeiko, Vadim; Kagansky, Alexander; Melino, Gerry; Barlev, Nikolai A.
- Abstract
Understanding the mechanisms that regulate cancer progression is pivotal for the development of new therapies. Although p53 is mutated in half of human cancers, its family member p73 is not. At the same time, isoforms of p73 are often overexpressed in cancers and p73 can overtake many p53 functions to kill abnormal cells. According to the latest studies, while p73 represses epithelial–mesenchymal transition and metastasis, it can also promote tumour growth by modulating crosstalk between cancer and immune cells in the tumor microenvironment, M2 macrophage polarisation, Th2 T-cell differentiation, and angiogenesis. Thus, p73 likely plays a dual role as a tumor suppressor by regulating apoptosis in response to genotoxic stress or as an oncoprotein by promoting the immunosuppressive environment and immune cell differentiation.
- Subjects
TUMOR microenvironment; DNA damage; EPITHELIAL-mesenchymal transition; CANCER invasiveness; CELL differentiation; TUMOR suppressor proteins
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 12, p3516
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10123516