We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Functional Restoration of Pituitary after Pituitary Allotransplantation into Hypophysectomized Rats.
- Authors
Choi, Jai Ho; Lee, Jung Eun; Kim, Hong-Lim; Ko, Seung Hyun; Kim, Se Hoon; Yang, Seung Ho
- Abstract
Long-term hormone replacement therapy due to panhypopituitarism can lead to serious complications and thus, pituitary transplantation is considered a more desirable. We investigated functional restoration after allotransplatation of the pituitary gland. We transplanted extracted pituitary gland into the omentum of an hypophysectomized rat. Two experiments were performed: (1) to confirm the hypophysectomy was successful and (2) to assess functional restoration after pituitary transplantation. Pituitary hormone level and weight change were consecutively assessed. Electron microscopic (EM) examinations were performed to identify morphological changes at 3 days after transplantation. We confirmed that pituitary gland was properly extracted from 6 rats after sacrifice. The findings showed (1) a weight loss of more than 3% or (2) a weight change of less than 2% along with a decreased growth hormone (GH) level by more than 80% at 2 weeks post-hypophysectomy. A further four rats underwent pituitary transplantation after hypophysectomy and were compared with the previously hypophysectomized rats. All showed rapid weight gain during the two weeks after transplantation. The thyroid-stimulating hormone, prolactin, and GH levels were restored at one week post-transplantation and maintained for 10 weeks. Hypophyseal tissue architecture was maintained at 3 days after transplantation, as indicated by EM. These data suggest that a transplanted pituitary gland can survive in the omentum with concomitant partial restoration of anterior pituitary hormones.
- Subjects
RATS; PITUITARY hormones; HORMONE therapy; SOMATOTROPIN; WEIGHT gain; CORAL reef restoration
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 2, p267
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10020267