We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A/ H1 N1 2009 influenza vaccine in England.
- Authors
Winstone, Anne Marie; Stellitano, Lesley; Verity, Christopher; Andrews, Nick; Miller, Elizabeth; Stowe, Julia; Shneerson, John
- Abstract
Aim The aim of this study was to investigate whether children in England with narcolepsy who received the ASO3 adjuvanted pandemic A/ H1 N1 2009 influenza vaccine ( Pandemrix) differed clinically from unvaccinated patients. Method A retrospective review was conducted in children with narcolepsy diagnosed by sleep centres and paediatric neurologists in 16 English hospitals. The inclusion criteria were patient age 4 to 18 years, onset of narcolepsy after January 2008, and diagnosis by the time of the key data-gathering visit in 2011. Clinical data came from hospital notes and general practitioner questionnaires. An expert panel validated the diagnoses. Results Seventy-five patients with narcolepsy were identified (43 males, 32 females; mean age at onset 10y 4mo, range 3-18y). Of these patients, 11 received the Pandemrix vaccine before narcolepsy onset. On first presentation, there were more frequent reports of cataplexy, among other features, in vaccinated than in unvaccinated patients (82% vs 55%), but only excessive weight gain (55% vs 20%) was significantly more frequent ( p=0.03). Facial hypotonia ( p=0.03) and tongue protrusion ( p=0.01) were eventually seen more frequently in vaccinated children. When considering patients diagnosed within a year of onset, vaccinated children were not diagnosed more rapidly than unvaccinated children. Interpretation Some symptoms and signs of narcolepsy were more frequently reported in Pandemrix-vaccinated patients. There was no evidence of the more rapid diagnosis in vaccinated patients that has been reported in Finland and Sweden.
- Subjects
ENGLAND; NARCOLEPSY; PANDEMICS; INFLUENZA vaccines; VACCINATION of children; PUBLIC health; SYMPTOMS; DIAGNOSIS
- Publication
Developmental Medicine & Child Neurology, 2014, Vol 56, Issue 11, p1117
- ISSN
0012-1622
- Publication type
Article
- DOI
10.1111/dmcn.12522