We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers.
- Authors
Mateu, César; Rodríguez-Arias, Marta; Gil-Miravet, Isis; Benito, Ana; Tomás, José M.; Haro, Gonzalo
- Abstract
Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders.
- Subjects
TANDEM repeats; COCAINE abuse; MONOAMINE oxidase; DIAGNOSIS; BASE pairs
- Publication
Brain Sciences (2076-3425), 2021, Vol 11, Issue 10, p1265
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci11101265