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- Title
Comparison of different aspects of BMI history to identify undiagnosed diabetes in Japanese men and women: Toranomon Hospital Health Management Center Study 12 (TOPICS 12).
- Authors
Yoshizawa, S.; Heianza, Y.; Arase, Y.; Saito, K.; Hsieh, S. D.; Tsuji, H.; Hanyu, O.; Suzuki, A.; Tanaka, S.; Kodama, S.; Shimano, H.; Hara, S.; Sone, H.
- Abstract
Aims To examine current BMI and various aspects of BMI history as pre-screening tools for undiagnosed diabetes in Japanese individuals. Methods This cross-sectional study included 16 226 men and 7026 women aged 30-75 years without a self-reported history of clinician-diagnosed diabetes. We estimated the probability of having undiagnosed diabetes (fasting glucose ⩾ 7.0 mmol/l and/or HbA1c ⩾ 48 mmol/mol (⩾ 6.5%) for the following variables: current BMI, BMI in the early 20s (BMI20y), lifetime maximum BMI (BMImax), change between BMI in the early 20s and current BMI (ΔBMI 20y-cur), change between BMI in the early 20s and maximum BMI (Δ20y-max), and change between lifetime maximum and current BMI (ΔBMI max-cur). Results The prevalence of undiagnosed diabetes was 3.3% (771/23252) among participants. BMImax, ΔBMI 20y-max and current BMI (1-SD increments) were more strongly associated with diabetes than the other factors (multivariate odds ratio 1.58 [95% CI 1.47-1.70] in men and 1.65 [95% CI 1.43-1.90] in women for BMI max; multivariate odds ratio 1.47 [95% CI 1.37-1.58] in men and 1.61 [95% CI 1.41-1.84] in women for ΔBMI 20y-max; multivariate odds ratio 1.47 [95% CI 1.36-1.58] in men and 1.63 [95% CI 1.40-1.89] in women for current BMI). The probability of having diabetes was markedly higher in those with both the highest tertile of BMImax and greatest ΔBMI 20y-max; however, a substantially lower likelihood of diabetes was observed among individuals with the lowest and middle tertiles of current BMI (< 24.62 kg/m2 in men and < 22.54 kg/m2 in women). Conclusions Lifetime maximum BMI and BMI changes from early adulthood were strongly associated with undiagnosed diabetes. Adding BMI history to people's current BMI would improve the identification of individuals with a markedly higher probability of having undiagnosed diabetes.
- Subjects
JAPANESE people; HEALTH; DIAGNOSIS of diabetes; THERAPEUTICS; HYPERTENSION; LIPID analysis; ACADEMIC medical centers; BLOOD pressure measurement; CONFIDENCE intervals; DIABETES; DIAGNOSIS; EPIDEMIOLOGY; HOSPITALS; MEDICAL errors; DISEASE management; DATA analysis; BODY mass index; CROSS-sectional method; ODDS ratio
- Publication
Diabetic Medicine, 2014, Vol 31, Issue 11, p1378
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.12471