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- Title
60 years of SOS repair.
- Authors
Zavilgelsky, G.
- Abstract
This review integrates 60 years of research on SOS repair and SOS mutagenesis in prokaryotes and eukaryotes, from Jean Weigle's experiment in 1953 (mutagenesis of lambda bacteriophage in UV-irradiated bacteria) to the latest achievements in studying SOS mutagenesis on all living organisms, i.e., Eukarya, Archaea and Bacteria. A key role in establishing of a biochemical basis for SOS mutagenesis belongs to the finding in 1998-1999 that specific error-prone DNA polymerases (PolV and others) catalyzed translesion synthesis on damaged DNA. This review focuses on recent studies that address new models for SOS-induced mutagenesis in Escherichia coli and Homo sapiens cells.
- Subjects
DNA repair; WEIGLE, Jean; BACTERIOPHAGE replication; MUTAGENESIS; DNA polymerases; ESCHERICHIA coli DNA
- Publication
Molecular Biology, 2013, Vol 47, Issue 5, p605
- ISSN
0026-8933
- Publication type
Article
- DOI
10.1134/S0026893313050221