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- Title
Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria.
- Authors
Rosa-Gonçalves, Pamela; Pereira de Sousa, Luciana; Barbosa Maia, Aline; Lima Ribeiro-Gomes, Flávia; Tavares de Lima Gress, Caroline Cristhiani; Loureiro Werneck, Guilherme; Onofre Souza, Diogo; Farina Almeida, Roberto; Tadeu Daniel-Ribeiro, Cláudio
- Abstract
Data recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of nonsevere rodent malaria caused by Plasmodium berghei ANKA. Here we explored the hypothesis that isolated immunization with one of the type 2 immune response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine, may revert damages associated with malaria. To investigate this possibility, we studied the dynamics of cognitive deficits and anxiety-like phenotype following non-severe experimental malaria and evaluated the effects of immunization with both dT and of a pool of type 2 immune stimuli in reversing these impairments. Locomotor activity and long-term memory deficits were assessed through the open field test (OFT) and novel object recognition task (NORT), while the anxiety-like phenotype was assessed by OFT and light/dark task (LDT). Our results indicate that poor performance in cognitive-behavioral tests can be detected as early as the 12th day after the end of antimalarial treatment with chloroquine and may persist for up to 155 days post infection. The single immunization strategy with the human dT vaccine showed promise in reversal of long-term memory deficits in NORT, and anxiety-like behavior in OFT and LDT.
- Subjects
MALARIA; RECOGNITION (Psychology); PSYCHONEUROIMMUNOLOGY; LONG-term memory; MEMORY disorders; IMMUNOREGULATION
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.1021211