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- Title
Pericyclases for cycloaddition.
- Authors
Zhang, Bo; Ge, Hui Ming
- Abstract
In the 1990s and 2000s, the enzymes macrophomate synthase, lovastatin polyketide synthase, solanapyrone synthase and riboflavin synthase were identified and proven to catalyse cyclohexene ring formation. Shortly after, Lei I et al. i identified the flavin adenine dinucleotide-dependent enzyme MaDA that can catalyse an intermolecular DA reaction to produce the isoprenylated flavonoid chalcomoracin in plant [[6]] (Fig. The Diels-Alder (DA) reaction is a simple yet very powerful pericyclic transformation involving the cycloaddition of a 1,3-diene and a dienophile to synthesize a cyclohexene ring via a cyclic transition state.
- Subjects
PERICYCLIC reactions; RING formation (Chemistry); CLAISEN rearrangement; ENE reactions; MORPHOLOGY; NOBEL Prize in Chemistry; REARRANGEMENTS (Chemistry); POLYKETIDES
- Publication
National Science Review, 2022, Vol 9, Issue 11, p1
- ISSN
2095-5138
- Publication type
Article
- DOI
10.1093/nsr/nwac229