We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
m<sup>7</sup> G regulator-mediated methylation modification patterns define immune cell infiltration and patient survival.
- Authors
Lu Wang; Xing Hu; Xiaoni Liu; Yingmei Feng; Yuan Zhang; Jing Han; Xuqing Liu; Fankun Meng
- Abstract
Numerous studies have demonstrated the important roles of epigenetic modifications in tumorigenesis, progression and prognosis. However, in hepatocellular carcinoma, the potential link between N7 -methylguanosine (m7 G) modification and molecular heterogeneity and tumor microenvironment (TME) remains unclear. Method: We performed a comprehensive evaluation of m7 G modification patterns in 816 hepatocellular carcinoma samples based on 24 m7 G regulatory factors, identified different m7 G modification patterns, and made a systematic correlation of these modification patterns with the infiltration characteristics of immunocytes. Then, we built and validated a scoring tool called m7 G score. Results: In this study, we revealed the presence of three distinct m7 G modification patterns in liver cancer, with remarkable differences in the immunocyte infiltration characteristics of these three subtypes. The m7 G scoring system of this study could assess m7 G modification patterns in individual hepatocellular carcinoma patients, could predict TME infiltration characteristics, genetic variants and patient prognosis. We also found that the m7 G scoring system may be useful in guiding patients’ clinical use of medications. Conclusions: This study revealed that m7 G methylation modifications exerted a significant role in formation of TME in hepatocellular carcinoma. Assessing the m7 G modification patterns of single patients would help enhance our perception of TME infiltration characteristics and give significant insights into immunotherapy efficacy.
- Subjects
OVERALL survival; HEPATOCELLULAR carcinoma; LIVER cancer; METHYLATION; TUMOR microenvironment
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.1022720