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- Title
Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study.
- Authors
Hyun Seok Bang; Dae Yun Seo; Young Min Chung; Do Hyung Kim; Sam-Jun Lee; Sung Ryul Lee; Hyo-Bum Kwak; Tae Nyun Kim; Min Kim; Kyoung-Mo Oh; Young Jin Son; Sanghyun Kim; Jin Han
- Abstract
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exerciseinduced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group). Participants were trained according to the RT program (60~80% of 1 repetition, 6 times/week), and the UA group was additionally given UA supplementation (450 mg/day) for 8 weeks. Blood samples were obtained before and after intervention, and cortisol, BNP, myoglobin, CK, CK-MB, and LDH levels were analyzed. Subjects who underwent RT alone showed no significant change in body composition and markers of skeletal muscle damage, whereas RT+UA group showed slightly decreased body weight and body fat percentage and slightly increased lean body mass, but without statistical significance. In addition, UA supplementation significantly decreased the BNP, CK, CK-MB, and LDH levels (p<0.05). In conclusion, UA supplementation alleviates increased skeletal muscle damage markers after RT. This finding provides evidence for a potential new therapy for resistance-trained men.
- Subjects
URSOLIC acid; SKELETAL muscle injuries; RESISTANCE training; MYOGLOBIN; CREATINE kinase; THERAPEUTICS
- Publication
Korean Journal of Physiology & Pharmacology, 2017, Vol 21, Issue 6, p651
- ISSN
1226-4512
- Publication type
Article
- DOI
10.4196/kjpp.2017.21.6.651