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- Title
Pharmacokinetics of boldenone and stanozolol and the results of quantification of anabolic and androgenic steroids in race horses and nonrace horses.
- Authors
SOMA, L. R.; UBOH, C. E.; GUAN, F.; MCDONNELL, S.; PACK, J.
- Abstract
Anabolic steroids (ABS) boldenone (BL; 1.1 mg/kg) and stanozolol (ST; 0.55 mg/kg) were administered i.m. to horses and the plasma samples collected up to 64 days. Anabolic steroids and androgenic steroids (ANS) in plasma were quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The limit of detection of all analytes was 25 pg/mL. The median absorption ( t1/2∂) and elimination ( t1/2 e) half-lives for BL were 8.5 h and 123.0 h, respectively, and the area under the plasma concentration–time curve ( ) was 274.8 ng·h/mL. The median t1/2 e for ST was 82.1 h and the was 700.1 ng·h/mL. Peak mean ( ) plasma concentrations ( Cmax) for BL and ST were 1127.8 and 4118.2 pg/mL, respectively. Quantifiable concentrations of ABS and ANS were found in 61.7% of the 988 plasma samples tested from race tracks. In 17.3% of the plasma samples two or more ABS or ANS were quantifiable. Testosterone (TES) concentrations mean ( ) in racing and nonracing intact males were 241.3 ± 61.3 and 490.4 ± 35.1 pg/mL, respectively. TES was not quantified in nonracing geldings and female horses, but was in racing females and geldings. Plasma concentrations of endogenous 19-nortestosterone (nandrolone; NA) from racing and nonracing males were 50.2 ± 5.5 and 71.8 ± 4.6 pg/mL, respectively.
- Subjects
STANOZOLOL; PHARMACOKINETICS; ANABOLIC steroids in animal nutrition; ANDROGENS; PHYSIOLOGICAL effects of testosterone; NANDROLONE; RACE horses; HORSE physiology; PHYSIOLOGY
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2007, Vol 30, Issue 2, p101
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.2007.00824.x