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- Title
Distribution of orally administered trimethoprim and sulfadiazine into noninfected subcutaneous tissue chambers in adult ponies.
- Authors
Van Duijkeren, E.; Ensink, J. M.; Meijer, L. A.
- Abstract
The distribution of trimethoprim (TMP) and sulfadiazine (SDZ) into subcutaneously implanted noninfected tissue chambers was studied in healthy adult ponies. Six ponies were given an oral TMP/SDZ paste formulation at a dose of 5 mg/kg TMP and 25 mg/kg SDZ at 12 h intervals for 2 days in order to reach steady-state concentrations. Plasma concentrations and tissue chamber fluid (TCF) concentrations of both drugs were measured at regular intervals during a period commencing 24 h after the last oral administration. The peak concentration of TMP (mean ± SD) was 2.92 ± 0.86 μg/mL for plasma and 1.09 ± 0.25 μg/mL for TCF. For SDZ, the mean peak concentration was 40.20 ± 14.74 μg/mL for plasma and 23.48 ± 5.84 μg/mL for TCF. TMP peak concentrations in plasma were reached at 3.17 ± 03.48 h and those in TCF at 7.33 ± 03.72 h. SDZ peak concentrations in plasma were reached at 1.83 ± 02.04 h and those in TCF at 8.00 ± 03.10 h. Concentrations of TMP and SDZ in TCF remained above the generally accepted breakpoint for susceptibility (0.5/9.5 for the TMP/SDZ combination) for 12 h. Therefore, in ponies oral administration of TMP/SDZ at a dose rate of 30 mg/kg given twice daily in the form of a paste should be appropriate for effective treatment of infections caused by susceptible bacteria.
- Subjects
TRIMETHOPRIM; PONIES; VETERINARY medicine
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2002, Vol 25, Issue 4, p273
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1046/j.1365-2885.2002.00418.x