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- Title
Differential Association of Generalized and Abdominal Obesity With Diabetic Retinopathy in Asian Patients With Type 2 Diabetes.
- Authors
Man, Ryan Eyn Kidd; Sabanayagam, Charumathi; Peggy Pei-Chia Chiang; Ling-Jun Li; Jonathan Edward Noonan; Jie Jin Wang; Tien Yin Wong; Chui-Ming Cheung, Gemmy; Siew Wei Tan, Gavin; Lamoureux, Ecosse L.; Chiang, Peggy Pei-Chia; Li, Ling-Jun; Noonan, Jonathan Edward; Wang, Jie Jin; Wong, Tien Yin; Cheung, Gemmy Chui-Ming; Tan, Gavin Siew Wei
- Abstract
<bold>Importance: </bold>The association between obesity and diabetic retinopathy (DR) is equivocal, possibly owing to the strong interrelation between generalized and abdominal obesity leading to a mutually confounding effect. To our knowledge, no study in Asia has investigated the independent associations of these 2 parameters with DR to date.<bold>Objective: </bold>To investigate the associations of generalized (defined by body mass index [BMI], calculated as weight in kilograms divided by height in meters squared) and abdominal obesity (assessed by waist to hip ratio [WHR]) with DR in a clinical sample of Asian patients with type 2 diabetes mellitus.<bold>Design, Setting, and Participants: </bold>This cross-sectional clinic-based study was conducted at the Singapore National Eye Centre, a tertiary eye care institution in Singapore, from December 2010 to September 2013. We recruited 498 patients with diabetes. After exclusion of participants with ungradable retinal images and type 1 diabetes, 420 patients (mean [SD] age, 57.8 [7.5] years; 32.1% women) were included in the analyses.<bold>Exposures: </bold>Body mass index and WHR as waist/hip circumference (in centimeters).<bold>Main Outcomes and Measures: </bold>The presence and severity of DR were graded from retinal images using the modified Airlie House Classification into none (n = 189), mild-moderate (Early Treatment Diabetic Retinopathy Study scale score, 20-41; n = 125), and severe DR (Early Treatment Diabetic Retinopathy Study scale score ≥53; n = 118). The associations of BMI and WHR with DR were assessed using multinomial logistic regression models adjusting for age, sex, traditional risk factors, and mutually for BMI and WHR.<bold>Results: </bold>Among the total of 420 patients, the median (interquartile range) for BMI and WHR were 25.7 (5.7) and 0.94 (0.08), respectively. In multivariable models, BMI was inversely associated with mild-moderate and severe DR (odds ratio [OR], 0.90 [95% CI, 0.84-0.97] and OR, 0.92 [95% CI, 0.85-0.99] per 1-unit increase, respectively), while WHR was positively associated with mild-moderate and severe DR (OR, 3.49 [95% CI, 1.50-8.10] and OR, 2.68 [95% CI, 1.28-5.62] per 0.1-unit increase, respectively) in women (P for interaction = .006). No sex-specific associations were found between BMI and DR (P for interaction >.10).<bold>Conclusions and Relevance: </bold>In Asian patients with type 2 diabetes, a higher BMI appeared to confer a protective effect on DR, while higher WHR was associated with the presence and severity of DR in women. Our results may inform future clinical trials to determine whether WHR is a more clinically relevant risk marker than BMI for individuals with type 2 diabetes.
- Subjects
SINGAPORE; ASIANS; DIABETIC retinopathy; GLYCOSYLATED hemoglobin; TYPE 2 diabetes; OBESITY; RETINA; RETINAL degeneration; BODY mass index; OPTICAL coherence tomography; CROSS-sectional method; WAIST-hip ratio
- Publication
JAMA Ophthalmology, 2016, Vol 134, Issue 3, p251
- ISSN
2168-6165
- Publication type
journal article
- DOI
10.1001/jamaophthalmol.2015.5103