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- Title
Effects of Antidepressive Treatment of Saint John's Wort Extract Related to Autonomic Nervous Function in Women with Irritable Bowel Syndrome.
- Authors
Hongyu Wan; Yulong Chen
- Abstract
Background and Aim: Irritable bowel syndrome (IBS) patients usually manifest autonomic nerve dysfunctions and abnormal psychological behaviors. This study was to assess autonomic nervous system (ANS) response to different stressor as well as evaluate effects of antidepressive treatment of Saint John's Wort Extract in women with IBS. Method: Thirty women with IBS and 20 healthy women underwent serial ANS function tests. Five-minute-short-time heart rate variability (HRV) spectral analysis were assessed at a stress or resting recording period. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to measure their anxiety and depression conditions. After 8-weeks' antidepressant treatment, groups of IBS repeated the tests above. Subjects also completed a GI symptom diary once daily during the 2 weeks before therapy and for 2 weeks in the last scheduled therapy session. Results: IBS-group showed a higher score in HAMA and HAMD (p p p Conclusions: Antidepressive treatment can improve the conditions of psychology and the ANS reactivity to stress in patients with IBS.
- Subjects
IRRITABLE colon; ANTIDEPRESSANTS; HYPERICUM; HERBAL medicine; AUTONOMIC nervous system; ALTERNATIVE treatment for mental depression; PATIENTS; THERAPEUTICS
- Publication
International Journal of Psychiatry in Medicine, 2010, Vol 40, Issue 1, p45
- ISSN
0091-2174
- Publication type
Article
- DOI
10.2190/PM.40.1.d