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- Title
Functional and structural MRI correlates of executive functions in multiple sclerosis.
- Authors
Marchesi, Olga; Bonacchi, Raffaello; Valsasina, Paola; Preziosa, Paolo; Pagani, Elisabetta; Cacciaguerra, Laura; Meani, Alessandro; Conti, Lorenzo; Mistri, Damiano; Rocca, Maria A; Filippi, Massimo
- Abstract
Background: Executive dysfunctions, including difficulties in attention, working memory, planning, and inhibition affect 15%–28% of multiple sclerosis (MS) patients. Objectives: To investigate structural and functional magnetic resonance imaging (MRI) abnormalities underlying executive function (EF) in MS patients. Methods: A total 116 MS patients and 65 controls underwent resting-state (RS) and diffusion-weighted sequences and neuropsychological examination, including Wisconsin Card Sorting Test (WCST) to test EF. Brain RS cognitive networks and fractional anisotropy (FA) from a priori selected white matter tracts were derived. Associations of WCST scores with RS functional connectivity (FC) and FA abnormalities were investigated. Results: In MS patients, predictors of working memory/updating were: lower corpus callosum (CC) FA, lower left working-memory network (WMN), right WMN RS FC for worse performance; lower executive control network (ECN), higher default-mode network (DMN), and salience network (SN) RS FC for better performance (R 2 = 0.35). Predictors of attention were lower CC genu FA, lower left WMN, and DMN RS FC for worse performance; higher left WMN and ECN RS FC for better performance (R 2 = 0.24). Predictors of worse shifting/inhibition were lower CC genu and superior cerebellar peduncle (SCP) FA, lower left WMN RS FC for worse performance; and higher ECN RS FC for better performance (R 2 = 0.24). Conclusions: CC and SCP microstructural damage and RS FC abnormalities in cognitive networks underlie EF frailty in MS.
- Subjects
EXECUTIVE function; FUNCTIONAL magnetic resonance imaging; WISCONSIN Card Sorting Test; CONTROL (Psychology); MULTIPLE sclerosis
- Publication
Multiple Sclerosis Journal, 2022, Vol 28, Issue 5, p742
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585211033184