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- Title
Novel combination therapy of hydroxychloroquine and topical tacrolimus for chronic ulcerative stomatitis.
- Authors
Stoopler, Eric T.; Kulkarni, Roopali; Alawi, Faizan; Sollecito, Thomas P.
- Abstract
Unlike most immune-mediated mucosal conditions, CUS typically does not respond favorably to corticosteroid therapy, however, it usually responds to antimalarials, such as hydroxychloroquine (HCQ), which is another distinguishing feature of this disease.2 A 53-year-old female complained of chronic symptomatic gingival and oral mucosal lesions of 6 months' duration. Clinical examination revealed diffuse oral ulcerations, Wickham's striae, and severe desquamation of the maxillary anterior gingiva (Fig. Dear Editor, Chronic ulcerative stomatitis (CUS) is a rare immune-mediated mucosal disorder characterized by symptomatic chronic oral ulcers not typically associated with cutaneous lesions.1 Because of similar clinical presentation to other conditions, such as oral lichen planus (OLP), diagnosis of CUS is challenging and often delayed.2 CUS is most commonly observed in middle-aged Caucasian females with mean age of onset and diagnosis at 57 and 62 years, respectively.2 Etiopathogenesis is associated with binding of the immunoglobulin IgG to Np63 , a nuclear protein located in the basal and parabasal layers of the stratified squamous epithelium, which results in separation of keratinocytes from each other and from the basement membrane.2 Clinical manifestations of CUS include Wickham's striae, erythema, and ulceration which commonly affect the buccal mucosa and tongue.
- Subjects
TACROLIMUS; HYDROXYCHLOROQUINE; STOMATITIS; ORAL lichen planus; BURNING mouth syndrome; DIAGNOSIS
- Publication
International Journal of Dermatology, 2021, Vol 60, Issue 4, pe162
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.15190