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- Title
Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma.
- Authors
Jiyeon Ahn; Ji Yun Park; Gyuri Kim; Sang-Man Jin; Kyu Yeon Hur; Soo-Youn Lee; Jae Hyeon Kim
- Abstract
Background: Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated. Methods: This is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group. Results: Urinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AUC than did urinary fractionated normetanephrine. The optimal cutoff for urinary free metanephrine and normetanephrine corrected for urinary creatinine yielded 97.2% sensitivity and 98.1% specificity. Conclusion: Urinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations compared with existing biochemical methods.
- Subjects
PHEOCHROMOCYTOMA; REFERENCE values; SENSITIVITY &; specificity (Statistics); ASIANS; DIAGNOSIS
- Publication
Endocrinology & Metabolism, 2021, Vol 36, Issue 3, p697
- ISSN
2093-596X
- Publication type
Article
- DOI
10.3803/EnM.2020.925