We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cardiovascular Outcomes according to Comorbidities and Low-Density Lipoprotein Cholesterol in Korean People with Type 2 Diabetes Mellitus.
- Authors
Min Kyong Moon; Junghyun Noh; Eun-Jung Rhee; Sang Hyun Park; Hyeon Chang Kim; Byung Jin Kim; Hae Jin Kim; Seonghoon Choi; Jin Oh Na; Young Youl Hyun; Bum Joon Kim; Kyung-Do Han; In-Kyung Jeong
- Abstract
Background: There are no clear data to support the cardiovascular (CV) risk categories and low-density lipoprotein cholesterol (LDL-C) treatment goals in Korean people with type 2 diabetes mellitus (T2DM). We evaluated the incidence of cardiovascular disease (CVD) according to comorbidities and suggested LDL-C treatment goals in Korean people with T2DM in nationwide cohort data. Methods: Using the Korean National Health Insurance Service database, 248,002 people aged 30 to 90 years with T2DM who underwent routine health check-ups during 2009 were included. Subjects with previous CVD were excluded from the study. The primary outcome was incident CVD, defined as a composite of myocardial infarction and ischemic stroke during the follow-up period from 2009 to 2018. Results: The mean age of the study participants was 59.6±10.9 years, and median follow-up period was 9.3 years. CVD incidence increased in the order of DM duration of 5 years or more (12.04/1,000 person-years), hypertension (HT) (12.27/1,000 personyears), three or more CV risk factors (14.10/1,000 person-years), and chronic kidney disease (18.28/1,000 person-years). The risk of incident CVD increased linearly from an LDL-C level of ≥70 mg/dL in most patients with T2DM. In T2DM patients without HT or with a DM duration of less than 5 years, the CVD incidence increased from LDL-C level of ≥100 mg/dL. Conclusion: For primary prevention of CVD in Korean adults with T2DM, it can be helpful to lower LDL-C targets when there are chronic kidney disease, HT, a long duration of diabetes mellitus, or three or more CV risk factors.
- Subjects
SOUTH Korea; LDL cholesterol; TYPE 2 diabetes; KOREANS; CARDIOVASCULAR diseases; NATIONAL health insurance; CHRONIC kidney failure
- Publication
Diabetes & Metabolism Journal, 2023, Vol 47, Issue 1, p45
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2021.0344