We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells.
- Authors
Ke, Po-Yuan
- Abstract
In eukaryotes, targeting intracellular components for lysosomal degradation by autophagy represents a catabolic process that evolutionarily regulates cellular homeostasis. The successful completion of autophagy initiates the engulfment of cytoplasmic materials within double-membrane autophagosomes and subsequent delivery to autolysosomes for degradation by acidic proteases. The formation of autolysosomes relies on the precise fusion of autophagosomes with lysosomes. In recent decades, numerous studies have provided insights into the molecular regulation of autophagosome–lysosome fusion. In this review, an overview of the molecules that function in the fusion of autophagosomes with lysosomes is provided. Moreover, the molecular mechanism underlying how these functional molecules regulate autophagosome–lysosome fusion is summarized.
- Subjects
CELL fusion; LYSOSOMES; AUTOPHAGY; PROTEOLYTIC enzymes
- Publication
Cells (2073-4409), 2024, Vol 13, Issue 6, p500
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells13060500