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- Title
B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes.
- Authors
Zouali, Moncef
- Abstract
Whereas autoimmune diseases are mediated primarily by T and B cells, auto-inflammatory syndromes (AIFS) involve natural killer cells, macrophages, mast cells, dendritic cells, different granulocyte subsets and complement components. In contrast to autoimmune diseases, the immune response of patients with AIFS is not associated with a breakdown of immune tolerance to self-antigens. Focusing on B lymphocyte subsets, this article offers a fresh perspective on the multiple cross-talks between both branches of innate and adaptive immunity in mounting coordinated signals that lead to AIFS. By virtue of their potential to play a role in adaptive immunity and to exert innate-like functions, B cells can be involved in both promoting inflammation and mitigating auto-inflammation in disorders that include mevalonate kinase deficiency syndrome, Kawasaki syndrome, inflammatory bone disorders, Schnitzler syndrome, Neuro-Behçet's disease, and neuromyelitis optica spectrum disorder. Since there is a significant overlap between the pathogenic trajectories that culminate in autoimmune diseases, or AIFS, a more detailed understanding of their respective roles in the development of inflammation could lead to designing novel therapeutic avenues.
- Subjects
KILLER cells; AUTOIMMUNE diseases; NEUROMYELITIS optica; B cells; LYMPHOCYTE subsets; MEVALONATE kinase
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 24, p4025
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11244025