We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ON THE MECHANISM OF IMMUNOLOGICAL TOLERANCE IN CYCLOPHOSPHAMIDE-TREATED MICE.
- Authors
Many, Amira; Schwartz, R. S.
- Abstract
The mechanism of immunological tolerance of sheep red blood cells (SRBC) in mice treated with a single dose of cyclophosphamide was studied. Specific tolerance lasted for as long as nine months in some animals, and its maintenance required the repeated administration of SRBC. Anti-SRBC antibody-forming cells were significantly reduced in the tolerant mice, and X-irradiated recipients of their ere specifically tolerant of SRBC. The smallest number of SRBC required for induction of tolerance was 107 this was the smallest number of SRBC that could elicit antibody synthesis within 5 days in normal mice. Since the effects of cyclophosphamide on antibody-forming cells last only 5 days, it was concluded mechanism of tolerance induction involved destruction of antigen- stimulated cells. In support of this is the finding that mice treated with small doses of cyclophosphamide were rendered tolerant only when SRBC were given before the drug. Drug-induced immunological tolerance thus appears to differ significantly from both pneumococcal polysaccharide paralysis and classical, acquired tolerance. A central loss of immunocompetence does not occur in the former, while the latter requires for its induction the administration of antigen in a dose or form that does not stimulate antibody synthesis.
- Subjects
IMMUNOLOGICAL tolerance; IMMUNOGLOBULINS; PHOSPHAZO compounds; ERYTHROCYTES; IMMUNE response; CELLS
- Publication
Clinical & Experimental Immunology, 1970, Vol 6, Issue 1, p87
- ISSN
0009-9104
- Publication type
Article