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- Title
The Potency of Nanoparticle of Pinus merkusii as Immunostimulatory on Male Wistar Albino Rat.
- Authors
Sudjarwo, Sri Agus; Wardani, Giftania; Eraiko, Koerniasari; Koerniasari
- Abstract
Objective: Medicinal herbs are the commonly used worldwide immunomodulators in the management of various disease conditions. The aim of this study was to evaluate the immunostimulatory activity of the nanoparticle extract of Pinus merkusii in Wistar albino rats. Materials and Methods: It was an experimental study that was conducted on various groups of animals each with six healthy adult rats. Neutrophil adhesion test, hemagglutinating antibody (HA) titer, delayed-type hypersensitivity (DTH) response, phagocytic activity, and cyclophosphamideinduced myelosuppression were determined in various groups of animals. Results: The nanoparticle of extract P. merkusii at doses 500 mg/kg BW but not at doses 125 mg/kg BW and 250 mg/kg BW induced a significant increase in percent neutrophil adhesion fibers as well as a dosedependent increase in antibody titer values and potentiated the DTH reaction induced by sheep red blood cells. Also, it prevented myelosuppression in cyclophosphamide drug-treated rats and good response toward phagocytosis in carbon clearance assay. Conclusion: From these findings, it can be concluded that nanoparticle extract of P. merkusii possesses immunostimulatory activity and has therapeutic potential for the prevention of immune-depressed conditions.
- Subjects
PINUS merkusii; LABORATORY rats; MYELOSUPPRESSION
- Publication
International Journal of Nutrition, Pharmacology, Neurological Diseases, 2018, Vol 8, Issue 1, p10
- ISSN
2231-0738
- Publication type
Article
- DOI
10.4103/ijnpnd.ijnpnd_72_17