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- Title
Opportunistic Infections in Patients with HTLV-1 Infection.
- Authors
Tanaka, Toshiki; Sekioka, Toshio; Usui, Masakatsu; Imashuku, Shinsaku
- Abstract
As an acquired immunodeficiency, human immunodeficiency virus (HIV) infection is primarily responsible for opportunistic infections in infected patients. However, opportunistic infections also occur in individuals with human T cell lymphotrophic virus type 1 (HTLV-1) infection. Here, we report opportunistic infections in two Japanese HTLV-1-seropositive patients. The first patient was a 67-year-old male, who had cytomegalovirus infection associated with esophagogastritis and terminal ileitis. The patient was HTLV-1-positive and was diagnosed with smoldering adult T cell leukemia (ATL). High levels of serum soluble IL-2 receptor (sIL-2R; 4,304 U/mL) and an increased percentage of CD4+CD25+ T cells (75.5%) in peripheral blood were also detected. The second patient was a 78-year-old female, a known asymptomatic HTLV-1 carrier, who presented with persistent herpes zoster, followed by Pneumocystis jirovecii pneumonia. Disease progression of smoldering ATL along opportunistic infections was observed with very high levels of serum sIL-2R (14,058 U/mL) and an increased percentage of CD4+CD25+ T cells (87.2%) in peripheral blood. In patients with suspected opportunistic infections, both HTLV-1 and HIV should be considered. In HTLV-1-positive patients, an increase in the CD4+CD25+ T cell subset may have its value as a prognostic marker.
- Subjects
HTLV-I infections; HIV infections; JAPANESE people; CYTOMEGALOVIRUS diseases; INTERLEUKIN-2 receptors; DISEASE progression; HEALTH
- Publication
Case Reports in Hematology, 2015, p1
- ISSN
2090-6560
- Publication type
Case Study
- DOI
10.1155/2015/943867