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- Title
Piscichuvirus-Associated Severe Meningoencephalomyelitis in Aquatic Turtles, United States, 2009-2021.
- Authors
Laovechprasit, Weerapong; Young, Kelsey T.; Stacy, Brian A.; Tillis, Steven B.; Ossiboff, Robert J.; Vann, Jordan A.; Subramaniam, Kuttichantran; Agnew, Dalen W.; Howerth, Elizabeth W.; Jian Zhang; Whitaker, Shayna; Walker, Alicia; Orgill, Andrew M.; Howell, Lyndsey N.; Shaver, Donna J.; Donnelly, Kyle; Foley, Allen M.; Stanton, James B.
- Abstract
Viruses from a new species of piscichuvirus were strongly associated with severe lymphocytic meningoencephalomyelitis in several free-ranging aquatic turtles from 3 coastal US states during 2009-2021. Sequencing identified 2 variants (freshwater turtle neural virus 1 [FTuNV1] and sea turtle neural virus 1 [STuNV1]) of the new piscichuvirus species in 3 turtles of 3 species. In situ hybridization localized viral mRNA to the inflamed region of the central nervous system in all 3 sequenced isolates and in 2 of 3 additional nonsequenced isolates. All 3 sequenced isolates phylogenetically clustered with other vertebrate chuvirids within the genus Piscichuvirus. FTuNV1 and STuNV1 shared ≈92% pairwise amino acid identity of the large protein, which narrowly places them within the same novel species. The in situ association of the piscichuviruses in 5 of 6 turtles (representing 3 genera) with lymphocytic meningoencephalomyelitis suggests that piscichuviruses are a likely cause of lymphocytic meningoencephalomyelitis in freshwater and marine turtles.
- Subjects
UNITED States; TURTLES; SEA turtles; CENTRAL nervous system; IN situ hybridization; REPTILES
- Publication
Emerging Infectious Diseases, 2024, Vol 30, Issue 2, p280
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid3002.231142