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- Title
Isolation and characterization of novel human parechovirus from clinical samples.
- Authors
Watanabe, Kanako; Oie, Masayasu; Higuchi, Masaya; Nishikawa, Makoto; Fujii, Masahiro
- Abstract
Using Vero cells, we isolated a virus (NII561-2000) from a cerebrospinal fluid specimen of a 1-year-old girl with Reye syndrome. The determined amino acid sequence of the virus indicated that the isolate was a human parechovirus (HPeV), a member of Picornaviridae. Neutralization test showed that the NII561-2000 virus had distinct antigenicity to HPeV-1, HPeV-2, and HPeV-3, and that the sequence was distinct from these types as well as from HPeV-4 and HPeV-5. Thus, we propose the virus (NII561-2000) as the prototype of HPeV-6. We isolated 10 NII561-2000-related viruses, 14 HPeV-1, 16 HPeV-3, and 1 HPeV-4 of 41 HPeVs from various clinical samples collected in Niigata, Japan. Clinical symptoms of the persons infected with the NII561-2000-related viruses were infectious gastroenteritis, rash, upper respiratory tract infection, and paralysis, in addition to Reye syndrome in the 1-year-old girl.
- Subjects
NIIGATA-shi (Japan); JAPAN; VIRUSES; REYE'S syndrome; SYNDROMES in children; PICORNAVIRUSES; JUVENILE diseases
- Publication
Emerging Infectious Diseases, 2007, Vol 13, Issue 6, p889
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid1306.060896