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- Title
Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors.
- Authors
Alaimo, Alessandro; Lorenzoni, Marco; Ambrosino, Paolo; Bertossi, Arianna; Bisio, Alessandra; Macchia, Alice; Zoni, Eugenio; Genovesi, Sacha; Cambuli, Francesco; Foletto, Veronica; De Felice, Dario; Soldovieri, Maria Virginia; Mosca, Ilaria; Gandolfi, Francesco; Brunelli, Matteo; Petris, Gianluca; Cereseto, Anna; Villarroel, Alvaro; Thalmann, George; Carbone, Francesco Giuseppe
- Abstract
Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), a cation channel characteristic of the prostate epithelium frequently overexpressed in advanced stage III/IV prostate cancers (PCa), sensitize therapy refractory models of PCa to radio, chemo or hormonal treatment. Overall, our study demonstrates that pharmacological-induced Ca2+ cytotoxicity is an actionable strategy to sensitize cancer cells to standard therapies.
- Publication
Cell Death & Disease, 2020, Vol 11, Issue 12, p1
- ISSN
2041-4889
- Publication type
Article
- DOI
10.1038/s41419-020-03256-5