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- Title
Clinical characteristics of familial schizophrenia.
- Authors
Liu, Na; Zhou, Hui; Xiong, Xiangyu; Li, Qingwei; Jiang, Xuefeng; Zhao, Jingping; Yang, Xiaoxin; Zhang, Mingyuan; Wang, Xiangqun; Wang, Gang; Yang, Fude; Hu, Jian; Zhang, Xinjun; Du, Lingyang; Li, Huichun; Feng, Bing; Hu, Zhenyu; Chen, Zuoming; Wang, Chunxia; Wang, Xilin
- Abstract
Introduction: A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated. Methods: This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia. Results: Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P =.004), tobacco dependence (OR = 1.48, P =.006), alcohol dependence (OR = 1.74, P =.013), and physical illness (OR = 1.89, P =.001) were independently and significantly associated with a family history of mental disease. Conclusion: Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.
- Subjects
SCHIZOPHRENIA; PSYCHOSES; PATIENT-family relations; LOGISTIC regression analysis; MULTIPLE regression analysis
- Publication
Asia-Pacific Psychiatry, 2021, Vol 13, Issue 2, p1
- ISSN
1758-5864
- Publication type
Article
- DOI
10.1111/appy.12422