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- Title
Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults.
- Authors
Sueyasu, Toshiaki; Yasumoto, Keisuke; Tokuda, Hisanori; Kaneda, Yoshihisa; Obata, Hidenori; Rogi, Tomohiro; Izumo, Takayuki; Kondo, Sumio; Saito, Jiro; Tsukiura, Takashi; Nakai, Masaaki
- Abstract
Arachidonic acid (ARA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), which are long-chain polyunsaturated fatty acids (LCPUFAs), as well as lutein (L) and zeaxanthin (Z), can potentially improve brain function. However, the effect of a combination of these components (LCPUFAs + LZ) on memory function in healthy older individuals remains unclear. This study aimed to determine if LCPUFAs + LZ-supplemented food could improve memory function. Exploratory and confirmatory trials (Trials 1 and 2, respectively) were conducted in healthy older Japanese individuals with memory complaints. We conducted randomized, double-blind, placebo-controlled, parallel-group trials. Participants were randomly allocated to two groups: placebo or LCPUFAs + LZ. LCPUFAs + LZ participants were provided with supplements containing ARA, DHA, EPA, L, and Z for 24 weeks in Trial 1 and 12 weeks in Trial 2. Memory functions were evaluated using Cognitrax before and after each trial. Combined analyses were performed for subgroups of participants with cognitive decline in Trials 1 and 2. The results showed that supplementation with LCPUFAs + LZ did not significantly affect memory function in healthy, non-demented, older individuals with memory complaints whereas it improved memory function in healthy, non-demented, older individuals with cognitive decline.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; UNSATURATED fatty acids; DOCOSAHEXAENOIC acid; RESEARCH; LUTEIN; HEALTH status indicators; ZEAXANTHIN; EICOSAPENTAENOIC acid; RANDOMIZED controlled trials; OMEGA-3 fatty acids; EPISODIC memory; BLIND experiment; DESCRIPTIVE statistics; ARACHIDONIC acid; DATA analysis software; ADULTS
- Publication
Nutrients, 2023, Vol 15, Issue 13, p2825
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15132825