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- Title
Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study.
- Authors
Elorz, Mariana; Benito-Boilos, Alberto; Marin, Bertha Araceli; Pérez Díaz del Campo, Nuria; Herrero, Jose Ignacio; Monreal, Jose Ignacio; Tur, Josep A.; Martínez, J. Alfredo; Zulet, Maria Angeles; Abete, Itziar
- Abstract
Neck circumference (NC) and its relationship to height (NHtR) and weight (NWtR) appear to be good candidates for the non-invasive management of non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the ability of routine variables to assess and manage NAFLD in 98 obese subjects with NAFLD included in a 2-year nutritional intervention program. Different measurements were performed at baseline, 6, 12 and 24 months. The nutritional intervention significantly improved the anthropometric, metabolic and imaging variables. NC was significantly associated with the steatosis degree at baseline (r = 0.29), 6 m (r = 0.22), 12 m (r = 0.25), and 24 m (r = 0.39) (all p < 0.05). NC was also significantly associated with visceral adipose tissue at all the study time-points (basal r = 0.78; 6 m r = 0.65; 12 m r = 0.71; 24 m r = 0.77; all p < 0.05). NC and neck ratios combined with ALT levels and HOMA-IR showed a good prediction ability for hepatic fat content and hepatic steatosis (at all time-points) in a ROC analysis. The model improved when weight loss was included in the panel (NC-ROC: 0.982 for steatosis degree). NC and ratios combined with ALT and HOMA-IR showed a good prediction ability for hepatic fat during the intervention. Thus, their application in clinical practice could improve the prevention and management of NAFLD.
- Subjects
NECK anatomy; NUTRITIONAL assessment; ANTHROPOMETRY; NON-alcoholic fatty liver disease; DIET therapy; WEIGHT loss; RECEIVER operating characteristic curves; ALANINE aminotransferase
- Publication
Nutrients, 2022, Vol 14, Issue 23, p5160
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14235160