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- Title
Curcumin Enhances the Antitumoral Effect Induced by the Recombinant Vaccinia Neu Vaccine (rV-neuT) in Mice with Transplanted Salivary Gland Carcinoma Cells.
- Authors
Focaccetti, Chiara; Benvenuto, Monica; Ciuffa, Sara; Fazi, Sara; Scimeca, Manuel; Nardi, Alessandra; Miele, Martino Tony; Battisti, Andrea; Bonanno, Elena; Modesti, Andrea; Masuelli, Laura; Bei, Roberto
- Abstract
The survival rate for head and neck cancer patients has not substantially changed in the last two decades. We previously showed that two rV-neuT intratumoral injections induced an efficient antitumor response and rejection of transplanted Neu (rat ErbB2/neu oncogene-encoded protein)-overexpressing salivary gland tumor cells in BALB-neuT mice (BALB/c mice transgenic for the rat ErbB2/neu oncogene). However, reiterated poxviral vaccinations increase neutralizing antibodies to viral proteins in humans that prevent immune response against the recombinant antigen expressed by the virus. Curcumin (CUR) is a polyphenol with antineoplastic and immunomodulatory properties. The aim of this study was to employ CUR administration to boost the anti-Neu immune response and anticancer activity induced by one rV-neuT intratumoral vaccination in BALB-neuT mice. Here, we demonstrated that the combined rV-neuT+CUR treatment was more effective at reducing tumor growth and increasing mouse survival, anti-Neu humoral response, and IFN-γ/IL-2 T-cell release in vitro than the individual treatment. rV-neuT+CUR-treated mice showed an increased infiltration of CD4+/CD8+ T lymphocytes within the tumor as compared to those that received the individual treatment. Overall, CUR enhanced the antitumoral effect and immune response to Neu induced by the rV-neuT vaccine in mice. Thus, the combined treatment might represent a successful strategy to target ErbB2/Neu-overexpressing tumors.
- Subjects
ANTINEOPLASTIC agents; ANIMAL experimentation; HEAD tumors; IMMUNIZATION; IMMUNOLOGICAL adjuvants; MICE; NECK tumors; POLYPHENOLS; RECOMBINANT proteins; SALIVARY gland tumors; SURVIVAL; CURCUMIN
- Publication
Nutrients, 2020, Vol 12, Issue 5, p1417
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12051417