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- Title
Effects of Periodic Fasting on Fatty Liver Index—A Prospective Observational Study.
- Authors
Drinda, Stefan; Grundler, Franziska; Neumann, Thomas; Lehmann, Thomas; Steckhan, Nico; Michalsen, Andreas; Wilhelmi de Toledo, Francoise
- Abstract
This prospective observational trial investigated effects and safety of periodic fasting in subjects with and without type 2 diabetes mellitus (T2DM). The primary end point was set as the change of fatty liver index (FLI) as a surrogate parameter of non-alcoholic fatty liver disease (NAFLD). Six-hundred and ninety-seven subjects (38 with T2DM) were enrolled. A baseline FLI ≥ 60 (the threshold for fatty liver) was found in 264 subjects (37.9%). The mean duration of fasting was 8.5 ± 4.0 days (range 6–38). FLI decreased significantly (−14.02 ± 11.67; p < 0.0001), with a larger effect in individuals with T2DM (−19.15 ± 11.0; p < 0.0001; p = 0.002 compared to non-diabetic subjects). Body mass index (BMI) decreased by −1.51 ± 0.82 kg/m2, and 49.9% of the subjects lost ≥5% body weight. After fasting, nearly half of the 264 subjects with FLI ≥ 60 (highest risk category) shifted to a lower category. The improvement of FLI correlated with the number of fasting days (r = −0.20, p < 0.0001) and with the magnitude of BMI reduction (r = 0.14, p = 0.0001). Periodic fasting with concomitant weight reduction leads to significant rapid improvement of FLI in subjects with and without T2DM.
- Subjects
BODY weight; FASTING; FATTY liver; LONGITUDINAL method; TYPE 2 diabetes; OBESITY; SCIENTIFIC observation; WEIGHT loss; BODY mass index; DESCRIPTIVE statistics
- Publication
Nutrients, 2019, Vol 11, Issue 11, p2601
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11112601