We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cynanchum wilfordii Etanolic Extract Controls Blood Cholesterol: A Double-blind, Randomized, Placebo-Controlled, Parallel Trial.
- Authors
Youn, Ji Sun; Ham, Young Min; Yoon, Weon-Jong; Choi, Ho-Chun; Lee, Ji Eun; Cho, Belong; Kim, Ji Yeon
- Abstract
We evaluated the effects of Cynanchum wilfordii (CW) ethanolic extract on blood cholesterol levels in adults with high low-density lipoprotein cholesterol (LDL-C) levels. In a double-blind, randomized, placebo-controlled, parallel trial, 84 subjects were recruited. Participants were randomly divided into two groups with a low-dose (300 mg/d) or high-dose (600 mg/d) of CW. Levels of very low-density lipoprotein (p = 0.022) and triglycerides (p = 0.022) were significantly lower in the low-dose CW group than in the placebo group after 8 weeks. In a subgroup of participants with LDL-C≥ 150 mg/dL (n = 33), there was a significant decrease in total cholesterol (low-dose, p = 0.012; high-dose, p = 0.021), apolipoprotein B (low-dose, p = 0.022; high-dose, p = 0.016), and cholesteryl ester transfer protein (low-dose, p = 0.037; high-dose, p = 0.016) after 8 weeks of CW. The correlation between changes in total cholesterol and baseline LDL-C levels was significant in the groups that received both doses of CW (low-dose, p = 0.010; high-dose, p = 0.015). These results show that the CW ethanolic extract can regulate blood cholesterol in subjects with LDL-C≥ 150 mg/dL.
- Subjects
DRUG therapy for hyperlipidemia; ANTILIPEMIC agents; APOLIPOPROTEINS; CARRIER proteins; CHOLESTEROL; GLYCOPROTEINS; LOW density lipoproteins; MEDICINAL plants; PLACEBOS; STATISTICAL sampling; TRIGLYCERIDES; PLANT extracts; RANDOMIZED controlled trials; BLIND experiment; PHARMACODYNAMICS
- Publication
Nutrients, 2019, Vol 11, Issue 4, p836
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11040836