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- Title
A circuit suppressing retinal drive to the optokinetic system during fast image motion.
- Authors
Mani, Adam; Yang, Xinzhu; Zhao, Tiffany A.; Leyrer, Megan L.; Schreck, Daniel; Berson, David M.
- Abstract
Optokinetic nystagmus (OKN) assists stabilization of the retinal image during head rotation. OKN is driven by ON direction selective retinal ganglion cells (ON DSGCs), which encode both the direction and speed of global retinal slip. The synaptic circuits responsible for the direction selectivity of ON DSGCs are well understood, but those sculpting their slow-speed preference remain enigmatic. Here, we probe this mechanism in mouse retina through patch clamp recordings, functional imaging, genetic manipulation, and electron microscopic reconstructions. We confirm earlier evidence that feedforward glycinergic inhibition is the main suppressor of ON DSGC responses to fast motion, and reveal the source for this inhibition—the VGluT3 amacrine cell, a dual neurotransmitter, excitatory/inhibitory interneuron. Together, our results identify a role for VGluT3 cells in limiting the speed range of OKN. More broadly, they suggest VGluT3 cells shape the response of many retinal cell types to fast motion, suppressing it in some while enhancing it in others. The optokinetic reflex assists image-stabilization in visual systems. Here the authors show that the slow speed preference of ON direction-selective ganglion cells, triggering optokinetic nystagmus, relies on inhibition from VGluT3 amacrine cells.
- Subjects
RETINAL ganglion cells; INTERNEURONS; IMAGE stabilization; RETINAL imaging; CELL morphology; NYSTAGMUS
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-40527-z