We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tumor Necrosis Factor-α-308 Gene Polymorphism in Croatian and Slovenian Multiple Sclerosis Patients.
- Authors
Ristić, Smiljana; Lovrečić, Luca; Starčević-Čizmarević, Nada; Brajenović-Milić, Bojana; Jazbec, Saša Šega; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut
- Abstract
Previous findings regarding the role of TNF-α-308 gene polymorphism in multiple sclerosis (MS) are contradictory. The aim of this study was to investigate the possible influence of TNF-α-308 polymorphism on MS susceptibility and the MS disease process in a Croatian and Slovenian population. Genotyping was performed in 338 patients and 460 healthy controls. The TNF2 allele was present in 123 (26.8%) healthy controls vs. 67 (19.9%) MS patients (p = 0.023, odds ratio = 0.68, 95% confidence interval = 0.48–0.95), suggesting that carriage of the TNF2 allele might decrease MS risk. The difference in TNF2 allele carrier frequency between patients and controls was identified in the relapsing-remitting MS group. There was no association between TNF2 allele carrier status and age at disease onset or disease progression. Our results suggest that, in the study populations, the TNF-α-308 polymorphism may play a role in MS susceptibility. Copyright © 2007 S. Karger AG, Basel
- Subjects
TUMOR necrosis factors; GENETIC polymorphisms; MULTIPLE sclerosis; DISEASE susceptibility; GENETIC research; CROATS; SLOVENES
- Publication
European Neurology, 2007, Vol 57, Issue 4, p203
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000099159