Develops a rapid diagnostic approach to individuals with the X-linked cytomegalic form of adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH) due to mutations in DAX1. Identification of DAX1 mutations in families that had males affected with AHC and the associated HH; Anticipatory management of HH and prenatal counseling for parents of the child.