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- Title
Assessment of vitamin D deficiency level by the physiological response of parathyroid hormone in Turkish adults.
- Authors
Vurgun, Eren; Evliyaoğlu, Osman; Vardar, Müberra
- Abstract
Objective: We aimed to contribute to the literature by determining deflection point of parathyroid hormone (PTH) level compared to 25-hydroxy vitamin D3 (25(OH)D3) level for determining the cut-off value of vitamin D deficiency level in Turkish adults. Methods: The levels of 25(OH)D3 and intact parathyroid hormone (iPTH) which were requested simultaneously in 1 year of 1684 adults were evaluated retrospectively. 25(OH)D3 levels were first classified as 80–50, 50–30, 30–25, 25–20, 20–15, 15–10, 10–5, 5–0 ng/mL and iPTH levels among those groups were compared. Results: First significant difference in iPTH levels was determined between 25(OH)D3 groups of 80–50 and 50–30 ng/mL (p=0.007). Second and third significant differences were determined between 25(OH)D3 groups of 15–10 and 10–5 ng/mL and between 10–5 and 5–0 ng/mL, respectively (p=0.006 and p=0.035, respectively). There were no differences in iPTH levels among seasons (p=0.11). Conclusion: In the light of these findings; we can state that iPTH levels are suppressed when 25(OH)D3 over 50 ng/mL, remains stable when 25(OH)D3 levels in between 50–10 ng/mL and gives the first increase response when 25(OH)D3 falls below 10 ng/mL. We believe that cut-off value for vitamin D deficiency in Turkish adults at all seasons depending on PTH response should be used as 10 ng/mL.
- Subjects
VITAMIN D deficiency; VITAMIN D; PARATHYROID hormone; CALCIUM regulating hormones; CHOLECALCIFEROL
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2018, Vol 43, Issue 5, p502
- ISSN
0250-4685
- Publication type
Article
- DOI
10.1515/tjb-2017-0265