We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Assessment of Viral Genotype Impact to the Cost-Effectiveness and Overall Costs of Care for Peg-Interferon-2α + Ribavirine Treated Chronic Hepatitis C Patients.
- Authors
Mihajlo, Jakovljevic B.; Zeljko, Mijailovic D.; Biljana, Popovska Jovicic D.; Predrag, Canovic S.; Olgica, Gajovic M.; Mirjana, Jovanovic R.; Dejan, Petrovic S.; Olivera, Milovanovic Z.; Natasa, Djordjevic D.
- Abstract
Background: Pegylated interferon alfa plus ribavirin protocol is currently considered the most efficient hepatitis C treatment. However, no evidence of costs comparison among common viral genotypes has been published. Objectives: We aimed to assess core drivers of hepatitis C medical care costs and compare cost effectiveness of this treatment among patients infected by hepatitis C virus with genotypes 1 or 4 (group I), and 2 or 3 (group II). Patients and Materials: Prospective bottom-up cost-effectiveness analysis from societal perspective was conducted at Infectious Diseases Clinic, University Clinic Kragujevac, Serbia, from 2007 to 2010. There were 81 participants with hepatitis C infection, treated with peg alpha-2a interferon plus ribavirin for 48 or 24 weeks. Economic data acquired were direct inpatient medical costs, outpatient drug acquisition costs, and indirect costs calculated through human capital approach. Results: Total costs were significantly higher (P = 0.035) in group I (mean ± SD: 12,751.54 ± 5,588.06) compared to group II (mean ± SD: 10,580.57 ± 3,973.02). In addition, both direct (P = 0.039) and indirect (P < 0.001) costs separately were significantly higher in group I compared to group II. Separate comparison within direct costs revealed higher total cost of medical care (P = 0.024) in first compared to second genotype group, while the similar tendency was observed for total drug acquisition (P = 0.072). Conclusion: HCV genotypes 1 and 4 cause more severe clinical course require more care and thus incur higher expenses compared to HCV 2 and 3 genotypes. Policy makers should consider willingness to pay threshold differentially depending upon HCV viral genotype detected.
- Subjects
SERBIA; ANALYSIS of variance; CLINICAL trials; COST effectiveness; GENES; HEPATITIS C; INTERFERONS; PROBABILITY theory; RESEARCH funding; RIBAVIRIN; STATISTICS; T-test (Statistics); DATA analysis; REPEATED measures design; DATA analysis software; DESCRIPTIVE statistics
- Publication
Hepatitis Monthly, 2013, Vol 13, Issue 6, p1
- ISSN
1735-143X
- Publication type
Article
- DOI
10.5812/hepatmon.6750