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- Title
Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts through C-N Bond Cleavage.
- Authors
Xiong, Biquan; Zhu, Longzhi; Feng, Xiaofeng; Lei, Jian; Chen, Tieqiao; Zhou, Yongbo; Han, Li‐Biao; Au, Chak‐Tong; Yin, Shuang‐Feng
- Abstract
A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.
- Subjects
CARBOXYLIC acids; AMIDES; COPPER research; AMINES; SCISSION (Chemistry)
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 20, p4244
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402332