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- Title
External validation of the PC-ECMO score in postcardiotomy veno-arterial extracorporeal membrane oxygenation.
- Authors
Biancari, Fausto; Juvonen, Tatu; Cho, Sung-Min; Hernández Pérez, Francisco J; L'Acqua, Camilla; Arafat, Amr A; AlBarak, Mohammed M; Laimoud, Mohamed; Djordjevic, Ilija; Samalavicius, Robertas; Alonso-Fernandez-Gatta, Marta; Sahli, Sebastian D; Kaserer, Alexander; Dominici, Carmelo; Mäkikallio, Timo
- Abstract
Reliable stratification of the risk of early mortality after postcardiotomy veno-arterial extracorporeal membrane oxygenation (V-A-ECMO) remains elusive. In this study, we externally validated the PC-ECMO score, a specific risk scoring method for prediction of in-hospital mortality after postcardiotomy V-A-ECMO. Overall, 614 patients who required V-A-ECMO after adult cardiac surgery were gathered from an individual patient data meta-analysis of nine studies on this topic. The AUC of the logistic PC-ECMO score in predicting in-hospital mortality was 0.678 (95%CI 0.630–0.726; p < 0.0001). The AUC of the logistic PC-ECMO score in predicting on V-A-ECMO mortality was 0.652 (95%CI 0.609–0.695; p < 0.0001). The Brier score of the logistic PC-ECMO score for in-hospital mortality was 0.193, the slope 0.909, the calibration-in-the-large 0.074 and the expected/observed mortality ratio 0.979. 95%CIs of the calibration belt of fit relationship between observed and predicted in-hospital mortality were never above or below the bisector (p = 0.072). The present findings suggest that the PC-ECMO score may be a valuable tool in clinical research for stratification of the risk of patients requiring postcardiotomy V-A-ECMO.
- Publication
International Journal of Artificial Organs, 2024, Vol 47, Issue 4, p313
- ISSN
0391-3988
- Publication type
Article
- DOI
10.1177/03913988241237701