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- Title
Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin–starch conjugates in rats.
- Authors
Hare, Gregory M. T.; Liu, Elaine; Baker, Andrew J.; Mazer, C. David
- Abstract
To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin–hydroxyethyl starch conjugate (HRC 101). Anesthetized rats were hemodiluted (180 ml kg−1) with low (P50 ~70 mmHg) or high affinity (P50 ~14 mmHg) HRC 101 at hemoglobin (Hb) concentrations near 100 or 70 g l−1 ( n = 6–8). Hippocampal tissue oxygen tension (PBrO2), blood flow, arterial blood gases, Hb, hematocrit (Hct) and lactate were measured. Data (mean ± SD) were analyzed by two-way ANOVA. Hemodilution reduced the hematocrit to 1 ± 1% in all groups. PBrO2 was best maintained after hemodilution with low affinity HRC 101 at Hb 100 and 70 g l−1 (25.2 ± 7.6 and 16.6 ± 8.3 torr, respectively). PBrO2 decreased (9.5 ± 9.3 torr, P < 0.05) and serum lactate levels increased (5.0 ± 1.7 mmol l−1, P < 0.05) following hemodilution with the high affinity HRC 101 (Hb 100 g l−1). HRC 101 with a lower oxygen affinity favored tissue perfusion and maintained PBrO2 after near complete blood volume exchange in rats.
- Subjects
TREATMENT of blood circulation disorders; CARDIOVASCULAR disease treatment; BLOOD viscosity; LABORATORY rats; HEMOGLOBINS
- Publication
Intensive Care Medicine, 2009, Vol 35, Issue 11, p1925
- ISSN
0342-4642
- Publication type
Article
- DOI
10.1007/s00134-009-1532-2